Tadarise-20 is a generic of the drug cialis, which is considered a high-quality and much cheaper alternative to It. Tadarise-20, as well as Cialis, contains 20 mg of tadalafil in its composition and it is one of the most popular brands today. Tadaris 20 is purchased by millions of men around the world who suffer from erectile dysfunction.
Description of the drug parameter Properties
Internal composition of Tadalafil 20 mg
Number CAS 171596-29-5
Group erectile Stimulators
The appearance of tablets, Oblong pills with no separating stripes
Package of Tablets in a container of 10 PCs.
Dosage Therapeutic doses of the active component of generic Cialis start from 5 mg. The dose can be increased to a maximum of 20 mg
Inactive substances are Croscarmellose, triacetin, yellow iron oxide, methyloxypropylcellulose, SLS and titanium dioxide.
The reception should be Used at least 1 hour before the expected intimate contact
Storage the date of storage is indicated on the package
Indication for treatment
Tadarise-20 is prescribed for the purpose of eliminating sexual disorders in men associated with impotence. The drug is intended to restore normal sexual response and establish the mechanism of erection in men. The active substance tadalafil is also registered under another brand “Adcirca”, which is used for the treatment of pulmonary arterial hypertension.
Composition of the drug
Tadalafil at a dose of 20 mg, is the main and only active substance of the drug Tadarayz-20.
Other inactive ingredients: croscarmellose, triacetin, yellow oxide, methyloxypropylcellulose, SLS and titanium dioxide.
Dosage and administration
Tadalafil should be taken well in advance, at least 40-80 minutes before the beginning of intercourse. Tadalafil has a huge advantage over other generics (Viagra or Levitra) — it works up to 48 hours after taking the pill. Thus, if sex is planned for the evening, then it is possible to take Tadarayz-20 even in the morning. Tadarise-20, unlike sildenafil, is tolerant of foods with a high fat content (French fries, chips), including alcohol. The method of application does not provide for 2 or more receptions per day. Exceeding the dose of 20 mg is fraught with an increase in the probability of undesirable side effects.
Use of Tadarise-20 over a long period of time
The use of Tadarise-20 by a continuous method allows you to fix the result for a long period of time and achieve a high-quality erection without using a means for potency, even after the end of the course. To do this, usually, a tablet with tadalafil is divided into four equal pieces and consumed 5 mg daily for a month. At the end of the course, men’s potency is stabilized and vascular system indicators are normalized. This method of using tadalafil course is much preferable than a single intake as needed. According to clinical studies, taking 5 mg of tadalafil daily is much safer than taking 20 mg of tadalafil once, side effects in this case are comparable to patients from the control group within the statistical error.
Single use immediately before sexual intercourse
With a single use of tadarayz-20, it is recommended to use 10-20 mg of tadalafil 40-80 minutes before the intended sexual contact, regardless of the meal, with a sufficient amount of water. Based on the fact that the effect of Tadarise-20 lasts up to 36 hours, the tablet can be taken much earlier. The recommended dosage of Tadarise cannot exceed the daily maximum therapeutic dosage of 20 mg, which is equal to one tablet of Tadaris 20.
Use in renal failure
People with insignificant decrease in renal function (creatinine clearance of 51 and less than 80 ml / min), had similar parameters of elimination of tadalafil with healthy volunteers in the control group. In patients with moderate renal dysfunction (creatinine clearance greater than 30 and less than 51 ml / min), there was a slight increase in the area under the concentration curve. For such patients, the dosage should be reduced to 10 mg of tadalafil per day. Scientific tests were not conducted with individuals with creatinine clearance of 30 ml / min or less.
Use in hepatic insufficiency
People with liver damage, mild to moderate severity (types A and B according to the child-Pugh typology) had an increased half-life of the substance. The area under the time-concentration curve and peak concentration increased by 84% and 47%, respectively, in comparison with patients of the same age, but without liver failure.
Patients with diabetes
Diabetes mellitus is a disease that often goes hand in hand with other comorbidities, including erectile dysfunction (ED). The difficulty lies in the fact that there are not so many proven medicines for the treatment of erectile dysfunction in diabetic patients.
The efficacy and safety of tadalafil were studied in four large multicenter, double-blind, randomized placebo-controlled trials with parallel groups of people, involving more than 2,000 subjects aged 18 to 85 years. One laboratory study was conducted with people suffering from diabetes, the next studied men who had undergone radical prostatectomy, the rest were conducted on a General basis, where the safety and effectiveness of tadalafil in the treatment of erectile reaction insufficiency of various origins, including psychogenic. In the group of patients with diabetes, over 20% of men had vascular complications, over 80% had a glycated hemoglobin level of more than 7.0% , and about 72% of men had severe or moderate ED, including 14 people (6%) with neuropathy and 23 people (11% of the total sample) with retinopathy. Tadalafil was used in these studies without restrictions on food or alcohol consumption. In addition to the lack of an erection, a large number of patients had many other physiological problems that directly or indirectly negatively affect erectile function. Almost 40% of patients had hypertension and used concomitant treatment with antihypertensive drugs simultaneously with tadalafil 20 mg. An interesting feature was noticed — patients who were treated simultaneously with antihypertensive drugs had a higher percentage of successful erections than other hypertensive patients who did not take them.
The result of all these studies did not depend on the initial concentration of glycated hemoglobin and can be considered quite successful. In subjects with type I and II diabetes, the effect of tadalafil was generally underestimated in comparison with patients without diabetes, but still by an order of magnitude greater than in the control group taking placebo. For patients with diabetes, the value of successful intravaginal penetrations, which maintained sufficient firmness of the penis throughout sexual activity, was 64% and 56% for dosages of 20 mg and 10 mg of tadalafil, respectively. The effectiveness of the substance had an inverse correlation with the neglect of the disease. A distinctive feature for diabetic patients with tadalafil use was a 19% reduction in systemic action time (AUC) compared to healthy volunteers. Similarly, the Cmax of tadalafil in blood plasma decreased. These small differences in pharmacokinetics are not grounds for dosage adjustment. Side effects for diabetic patients were the same as for healthy volunteers from the control group.
The age of men is not a belief for reducing the dose. If there are no other contraindications, then the dose of Tadarise-20 should be standard — up to 20 mg for a single dose and 5 mg, if the patient is undergoing prolonged treatment with tadalafil for a month or more.
Contraindications and precautions
Intolerance to the active substance or medication in General.
Painful potency that lasts for more than four hours (priapism). Patients who have previously had a history of priapism that lasted more than 4 hours, or have diseases that contribute to priapism ( Peyronie’s disease, myeloma, cavernous fibrosis, thrombocytopenia, acute leukemia, sickle cell anemia), should refuse to use generic Cialis and other phosphodiesterase inhibitors.
Acute stages of heart disease: Beck’s triad, heart attack (over the past six months), heart failure (class II-IV according to NYHA systematization), hypertrophic obstructive cardiomyopathy, coronary heart disease (CBS), increased QT interval duration (both congenital QT prolongation and the use of certain medications to increase QT), unstable angina and aortic stenosis.
Severe kidney and liver condition: Tadarise-20 is contraindicated in subjects with acute chronic kidney disease (CC less than 30 ml / min) and severe liver damage.
Diseases of the vascular system: arterial hypertension (upper more than 170 mm Hg, lower more than 110 mm Hg), stroke (within the last 6 months), significant hypotension (less than 90/50).
Ulcer of the gastrointestinal tract. Laboratory tests of tadalafil in vitro revealed a slight antithrombotic effect on the blood clotting process. Therefore, persons with an active phase of gastrointestinal ulcers and impaired blood clotting function should exclude generic Cialis, at least for the time being, while there is a risk of bleeding.