What is Nizagara-100?
Nizagara-100 is a generic Viagra intended for the treatment of sexual disorders in men. This generic is prescribed for the purpose of restoring normal sexual response and establishing the mechanism of erection in men. Each nizagara-100 tablet contains 100 mg of sildenafil citrate.
Nizagara-100 specificationfrequency Properties
Trade name Nizagara-100
Active substance Sildenafil
CAS-active substance number 171599-83-0
Manufacturer Sunrise Remedies Pvt. LTD
Pharmacological group of Regulators potency
Dosage form Tablets 100 mg
Composition sildenafil citrate 100 mg; Additional substances: titanium dioxide (E 171), lactose. anhydrous calcium hydrogen phosphate, magnesium stearate
Recommended dose the Initial recommended dose is 50 mg, which is equivalent to half a tablet
Method of use Before meals, on an empty stomach. 40 minutes — 1 hour before intimate contact
The color of the Tablet is uniform blue, without labels
Purity 96% ~ 101%
Shelf life is 36 months from the date of manufacture (the end date of storage is indicated on the package)
The drug Nizagara-100 belongs to the class of selective phosphodiesterase-5 inhibitors. Group — “potency Regulators and remedies for the treatment of erectile dysfunction”. Nizagara-100 is used to correct erectile dysfunction, including those of psychogenic origin.
Active substance: Sildenafil citrate.
Excipients: anhydrous calcium hydrophosphate, lactose, food coloring-titanium dioxide, magnesium stearate.
Indications for use
Nizagara-100 is a drug for the treatment of erectile dysfunction, various erectile disorders, including organic, psychogenic or mixed (F52.2).
Dosage and method of use
Nizagara is taken orally, with a sufficient amount of water. The recommended dose, in the prevailing majority, is 50 mg (half of the tablet). If the effect in this case is insufficient-the daily dose can be increased to 100 mg, or Vice versa, if the effect is too pronounced and there are side effects-the dose can be reduced to 25 mg (a quarter of a tablet).
Dosage for impaired renal function
Light and medium forms do not require correction of sildenafil. In acute and chronic renal failure (creatinine concentration less than 30 ml/min), sildenafil has not been studied.
Dosage for impaired liver function
If there is a violation of liver function, including cirrhosis, the dosage of the drug should be reduced to 25 mg (a quarter of a tablet). And since the half-life of sildenafil with impaired liver function is significantly increased, malegra should not be taken more often than once every 48 hours.
Experiments show that with an increase in the dosage exceeding the maximum therapeutic dose, the risk of side effects increases. In this situation, you need to use symptomatic therapy as a treatment. In this case, hemodialysis has no effect, because sildenafil after entering the blood actively binds to its proteins.
Combination of Malegra with alcohol
Joint use of sildenafil with alcohol is not desirable. Patients who have taken alcohol together with Malegra significantly increase the likelihood of side effects in the form of headaches. Alcohol also affects the speed and strength of Malegra, significantly delaying the onset of the effect.
Studies of sildenafil at a dose of 50 mg did not confirm that the latter increases the hypertensive or hypotensive effects of alcohol in male volunteers and all indicators were within the arithmetic error.
Mechanism of action of Nizagara-100
The Sildenafil molecule and the mechanism of erection are quite complex and not fully understood. It is known that an erection is triggered by excitation of the cerebral cortex and the transmission of nerve impulses to the cells of the penis. Under the influence of this effect, the active synthesis of nitric oxide (NO) begins, which triggers another specific enzyme – guanylate cyclase. Under the influence of the latter, the synthesis of cyclic guanosine monophosphate (cGMP) begins.
Outside of an erection, there is a relative excess of CA+ calcium ions in the cells of the penis, which maintains the tone of the special muscles of the penis (m. Ischiocavernosus) in an unexcited state. The increased synthesis of cGMP by cells of the penis leads to a decrease in the concentration of Ca+, causing the muscles of corpora cavernosa relax and increases arterial blood inflow to cavernous bodies of the drive and reduced the outflow of venous blood comes an erection. In response to this, in various disorders, premature synthesis of a special enzyme begins – PDE-5, which is intended for hydrolysis and cleavage of cGMP. As a result, Ca+ again decreases in the cells and increases the outflow of venous blood, in other words, the erection stops, and the penis falls, in severe cases, even without rising.
The active component of Nizagara-100-sildenafil citrate, is nothing other than a PDE-5 inhibitor and shows greater affinity for this enzyme than for other phosphodiesterases. Viagra has a similar structure to cGMP and actively binds to PDE-5 , thereby preventing the destruction of cGMP, and maintains an erection at a longer level.
Nizagara is usually well tolerated in healthy men with erectile dysfunction, with a single dose of up to 100 mg / day, does not cause addiction and any other physiological disorders in the long term. The standard dosage does not change for the elderly unless prescribed by a doctor, and usually starts at 50 mg, not exceeding the maximum daily dose.
Side effects of Nizagara
Nizagara, usually well tolerated. In some cases, standard side effects were recorded, which are of a minor nature and a fairly low frequency of manifestation:
from the Central nervous system: spasm of skeletal muscles and increased tone, insomnia, dizziness;
from the cardiovascular system: headache, fever in the face;
from the musculoskeletal system (muscle and joint pain);
from the gastrointestinal tract (dyspepsia, diarrhea, nausea);
from the skin (rash, itching);
from the organs of perception of the surrounding world (impaired vision clarity, color perception changes, nasal congestion).
from the reproductive side: priapism.
Side effects of Nizagara
Among other side effects, post-research reports have documented very rare cases of hearing loss in one ear or vision loss – about 500 people out of 23 million receiving. But it was never possible to prove what really caused such an extremely unusual reaction to sildenafil, co-administration with other medications, or anything else.
Contraindications to the use of Nizagara
Contraindications for taking Nizagara-100 are: individual intolerance to sildenafil and hypersensitivity to any other components of the drug.
Also, taking this drug should be avoided with such individual characteristics of the body:
exacerbation of duodenal ulcer and stomach ulcer;
severe renal and liver failure;
diseases of blood-forming functions (multiple myeloma, sickle cell anemia, leukemia);
especially severe forms of hypertension or hypotension, unstable angina, especially dangerous forms of arrhythmia and cardiac safety;
predisposition to priapism and men with congenital penile curvature and fibrosis.
a relatively recent stroke or myocardial infarction (up to 6 months).
women and children under the age of 18 due to lack of information on clinical trials.
joint simultaneous intake of nitrates and nitrogen donors is strictly prohibited due to the risk of instantaneous pressure reduction.
pregnancy. Sildenafil, although it was tested on rats and rabbits, which studied the reaction to the fetus, but these data can not be interpolated for pregnant women and their intrauterine children. No abnormalities in the formation of the fetus in rats and rabbits were not identified.
Interaction with other medications
With simultaneous use of cimetidine, erythromecin and ketoconazole, it is possible to reduce clearance, as well as increase the area under the concentration curve. Simultaneous joint administration of hypoglycemic drugs, beta-blockers and bmcc is also considered unsafe. Another very dangerous combination is the joint use of sildenafil with nitrogen donators and other nitrates, due to a possible sharp decrease in blood pressure.
Type and form of issue
Nizagara is sold as blue tablets in a foil container. Nizagara-100 contains 100 mg of sildenafil citrate-in each tablet (the active substance of Nizagara). In addition to the active ingredients, it contains a number of neutral excipients: magnesium sterate, titanium dioxide, MCC, anhydrous calcium phosphate, and lactose.
Nizagara-100 should be stored in a cool and dry place, away from children and direct sunlight. The storage temperature should not exceed 30 °C. The final shelf life is indicated on the package and should not exceed 3 years.